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- Original article -
Severe Palmo-Plantar Hyperkeratosis in Koebner Epidermolysis Bullosa Simplex
Yuji Shirakata, Katsuto Tamai*, Hiroki Nakaoka, Sho Tokumaru, Koji Sayama, Shinji Murakami and Koji Hashimoto
Department of Dermatology, Ehime University School of Medicine, Ehime, Japan.
*Department of Dermatology, Hirosaki University School of Medicine, Hirosaki, Japan.
A 22-year-old Japanese woman with Koebner epidermolysis bullosa simplex presented with severe palmo-plantar hyperkeratosis. Skin biopsy specimens from the palm revealed hyperkeratosis and acanthosis with blistering in the basal cell layer. An electron microscopic study showed cytolysis of basal cells and clumping of tonofilaments forming thick bundles and perinuclear electron-dense bodies. Hand contractures were released and covered with full thickness autografts or split thickness autografts. The donor site was successfully treated with cultured epidermal autografts.
key words: epidermolysis bullosa simplex; Koebner variant; palmo-plantar hyperkeratosis; skin graft; cultured epidermal autograft
Received August 28, 2002; Accepted for publication November 21, 2002
Reprint requests to: Yuji Shirakata, M.D., Department of Dermatology, Ehime University School of Medicine, Shitsukawa, Shigenobucho, Onsengun, Ehime 791-0295, Japan.
J Dermatol 30 (2): 135-140, 2003
Japanese Dermatological Association
http://www.dermatol.or.jp
