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- Original article -
Nonspecific Cell-Mediated Immunity in Patients with Epidermodysplasia Verruciformis
Walmar Roncalli Pereira de Oliveira*,**, Solange Carrasco*, Cyro Festa Neto*, Peter Rady** and Stephen K. Tyring**,***
*Department of Dermatology of University of São Paulo, Brazil.
Departments of **Microbiology and Immunology and ***Dermatology of University of Texas Medical Branch, Galveston, Texas, U.S.A.
Epidermodysplasia verruciformis (EV) is a rare disease that usually begins in childhood and is characterized by a generalized infection by human papilloma virus (HPV), frequent associations with cutaneous carcinomas, and abnormalities of cell-mediated immunity (CMI). We studied nonspecific CMI in 13 patients with EV by bacterial skin tests, allergic reactions to dinitrochlorobenzene (DNCB), measurement of responses to phytohemagglutinin (PHA), and quantification of T lymphocytes and T lymphocytes subsets in peripheral blood. Impairment of CMI was manifested by the cutaneous anergy to a variety of common skin antigens and, by the reduction of the lymphocyte transformation to PHA. There were no correlation between the severity of cases and abnormalities of CMI in our patients, however; the impairment of CMI was lower in cases of short duration, suggesting that the impairment of CMI in EV might reflect a long period of disease.
key words: epidermodysplasia verruciformis; cell-mediated immunity; human papilloma virus; DNCB sensitization; lymphocyte transformation
Received April 22, 2002; Accepted for publication January 15, 2003
Reprint requests to: Walmar Roncalli Pereira de Oliveira, Rua Monte Alegre 428 conj. 13, Perdizes, São Paulo-SP, Brazil, 05014.000.
J Dermatol 30 (3): 203-209, 2003
Japanese Dermatological Association