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- Original article -
A Case of Antiphospholipid Syndrome with Cutaneous Ulcer and Intrauterine Fetal Growth Retardation
Junji Nakano, Mitsutaka Nakamura, Takehisa Ito*, Masako Murata** and Jun-ichi Fujiyama***
Department of Dermatology, Tokuyama Central Hospital, Tokuyama, Japan.
*Department of Obstetrics and Gynecology, Tokuyama Central Hospital, Tokuyama, Japan.
**Hikari Dermatology Clinic, Hikari, Japan.
***Department of Dermatology, Hikari City Hospital, Hikari, Japan.
A 28-year-old patient presented with severe intrauterine fetal growth retardation (IUGR) at 34 weeks' gestation. There was a prior history of a recurrent cutaneous ulcer on the left thigh. Serological tests for IgG anticardiolipin antibody were positive. A live premature male infant was delivered by an urgent cesarean section because of fetal distress. Histopathological examination revealed that the causes of the cutaneous ulcer and IUGR were thrombosis of the small blood vessels and placental infarction, respectively. Early diagnosis and proper treatment are important in the management of the antiphospholipid syndrome.
key words: antiphospholipid syndrome; cutaneous ulcer; thrombosis of the small blood vessels; intrauterine fetal growth retardation; placental infarction
Received October 10, 2002; Accepted for publication March 25, 2003
Reprint requests to: Junji Nakano, M.D., Department of Dermatology, Tokuyama Central Hospital, 1-1 Koda-cho, Tokuyama 745-8522, Japan.
J Dermatol 30 (7): 533-537, 2003
Japanese Dermatological Association
http://www.dermatol.or.jp
