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- Original article -
Dilated Pore: A Case Report and an Immunohistochemical Study of Cytokeratin Expression
Takahito Morikawa, Hajime Takizawa, Takamitsu Ohnishi and Shinichi Watanabe
Department of Dermatology, Teikyo University School of Medicine, Tokyo, Japan.
We report a 71-year-old Japanese female with a dilated pore in the form of a nodule above her right eyebrow. Histologic examination revealed a flask-shaped, keratinous cystic structure that was continuous with the surface epidermis and had numerous elongated rete ridges in the lower portion. An immunohistochemical study using a panel of monoclonal antibodies against cytokeratins (CKs) and involucrin detected CK1 and CK10 in the suprabasal cells of the cystic structure. CK8 and CK19 expression was observed in the outermost layer of some elongated rete ridges; it was composed of pallisading columnar cells. Most parts of the outermost layer of the cystic structure stained positively with AE1 antibody. From these immunohistochemical findings, we speculated that the dilated pore in our case was an isolated clinical entity is a follicular tumor differentiating mainly toward the infundibulum and partly toward the isthmus.
key words: dilated pore; immunohistochemical study; infundibular tumor
Received December 2, 2002; Accepted for publication March 25, 2003
Reprint requests to: Takahito Morikawa M.D., Department of Dermatology, Saitama Kyou-dou Hospital, Kizoro 1317, Kawaguchi-City, Saitama, 333-0831, Japan.
J Dermatol 30 (7): 556-558, 2003
Japanese Dermatological Association
http://www.dermatol.or.jp
