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[Vol.32 No.12 content]

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Article in English

- Original article -

A Case of Angiolymphoid Hyperplasia with Eosinophilia (ALHE) of the Upper Lip

Hiromi Suzuki, Atsushi Hatamochi, Masaki Horie, Toshihiro Suzuki and Soji Yamazaki
Department of Dermatology, Dokkyo University School of Medicine, Mibu, Japan
Angiolymphoid hyperplasia with eosinophilia (ALHE) is clinically characterized by intradermal or subcutaneous papules and/or nodules usually occurring in young adults. Lesions in the oral mucosa are extremely rare. We report a case and review the literature of ALHE cases involving the oral mucosa. A 40-year-old man presented with a painless, 20 × 20 mm, submucosal nodule on the upper lip. Histological examination of lip biopsy specimens revealed an increase in many small vessels. The vascular walls consisted of prominent endothelial cells with a histiocytoid appearance, which protruded into the lumen. Many eosinophils and lymphocytes were also seen around the vessels. The diagnosis of ALHE was made from the above findings.
key words: angiolymphoid hyperplasia with eosinophilia (ALHE); Kimura's disease (KD); oral mucosa, upper lip

Received April 11, 2005; Accepted for publication July 15, 2005
Reprint requests to: Hiromi Suzuki, M.D., Department of Dermatology, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu, Tochigi 321-0293, Japan

J Dermatol 32 (12): 991-995, 2005

Japanese Dermatological Association