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[Vol.32 No.12 content]

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Article in English

- Original article -

A Case of Nodular Scleroderma

Lucilla Melani, Marzia Caproni, Carla Cardinali, Emiliano Antiga, Elisabetta Bernacchi*, Emiliano Schincaglia and Paolo Fabbri
Department of Dermatological Sciences, University of Florence, Italy
*Department of Internal Medicine, University of Pisa, Italy
Nodular scleroderma is a rare complication of systemic sclerosis; the pathogenetic implications are still unknown, although many factors are supposed to play a role in lesion development. We report the case of a young woman suffering from systemic sclerosis, who developed nodular lesions during therapeutic management with D-penicillamine and plasmapheresis. In order to better understand the essence of this disease, we examined all the possible pathogenetic mechanisms that could be implicated in nodular lesion development.
key words: nodular scleroderma; systemic sclerosis

Received October 25, 2004; Accepted for publication June 6, 2005
Reprint requests to: Marzia Caproni, Dipartimento di Scienze Dermatologiche, Università degli Studi di Firenze, Via della Pergola 58/60, 50121 Firenze, Italy

J Dermatol 32 (12): 1028-1031, 2005

Japanese Dermatological Association